Reductil sibutramine for weight loss!

July 13, 2009

Reductil sibutramine is categorized as an appetite suppressant weight loss drug. Reductil was approved by the FDA in 1997 as a prescription only weight loss drug. Since then Reductil sibutramine has helped number of obese people to effectively lose weight and lead a more healthy life.

Reductil sibutramine is recommended to patients who do not derive satisfactory weight loss results from regular means such as dieting and exercise. Though proved effective as a weight loss aid, Reductil sibutramine does not guarantee weight loss by its own. Reductil will only help people who are determined to lose weight and who use the drug in conjunction with a reduced calorie diet and exercise.

Sibutramine – the active ingredient in Reductil works on the neurotransmitters in the brain and dupes your brain to feel ‘full’ even when you have eaten less. Further, Reductil sibutramine also reduces craving in between meals so that you are not tempted to eat those high-calorie snacks. Thus by reducing your appetite, Reductil sibutramine controls the calorie in-take and thereby helps you to gradually loss weight.

Proper use of Reductil sibutramine

To achieve best weight loss results, one should make proper use of Reductil sibutramine. Given here is important information that will help you make proper use of Reductil sibutramine.

Always consult your doctor before using Reductil sibutramine and inform in detail about your general health conditions and medicines you may be taking. This will help your doctor determine the suitability of Reductil in your case and also determine the right Reductil sibutramine dosage for you.

The standard recommended dose of Reductil sibutramine is once daily, generally in the morning before your first meal. Reductil treatment is usually started with one 10mg tablet one day. However, your doctor may increase your dosage to 15mg depending on the effectiveness of the drug in your body and also on your tolerance to sibutramine. The dosage may also be reduced to 5mg if the 10mg treatment is not tolerated well by your body. In any case, do not alter the Reductil sibutramine dosage without first consulting your doctor.

Precautions to take before using Reductil sibutramine

Reductil sibutramine is a prescription only drug hence one should use proper precautions before using the drug for weight loss. This section offers you important information on precautions to take before using Reductil sibutramine weight loss drug.

While considering Reductil sibutramine treatment with your doctor either face-to-face or via online consultations always offer detailed information about your general health conditions and any type of prescription or OTC medicine that you may be taking. This will help your doctor to determine if Reductil will be appropriate for you and also determine the dosage.

■Do not use Reductil sibutramine if you have eating disorders, high blood pressure, and hardening of the arteries, have had a stroke.
■Do not use Reductil sibutramine if you have history of seizures, are taking another appetite suppressant, if you have taken anti-depressant monoamine oxidase inhibitor (MAO) inhibitor (eg, phenelzine) within the last 14 days.
■Do not use Reductil sibutramine if you have severe liver or kidney problems, hemophilia or other bleeding problems
■Do not use Reductil sibutramine if you are suffering from depression or if you have a history of depression.
■Do not use Reductil sibutramine if you are pregnant, breastfeeding or below 18 years of age.
■Caution is also advised in patients who have epilepsy or sleep apnea.
■Inform your doctor if you have glaucoma (an eye disease) or Parkinson’s disease.
■Inform your doctor if you have any allergies or if you have a known sensitivity to any of the ingredients of Reductil sibutramine.
■Inform your doctor immediately if you experience any bothersome Reductil side effects.
Tests on Reductil sibutramine

Reductil sibutramine is proven to be a safe and effective weight-loss drug in the numerous clinical trials that were conducted before the drug was approved for use. When used in conjunction with a reduced-calorie diet and proper physical activity, about 77 percent of patients achieved weight loss that benefited their health.

Eleven double-blind, placebo-controlled obesity trials were conducted on weight loss using Reductil. Study length varied from 12 to 52 weeks and doses ranged from 1 to 30 mg once daily. Weight was significantly lowered when doses varied from 5-20mg in Reductil treated patients as opposed to those treated with a placebo. In two 12-month studies, greatest level of weight loss was gained by 6 months and significant weight loss was upheld across the 12 months.

Unexpected Microbe Diversity on Human Skin

July 2, 2009

A new study of the skin’s microbiome—all of the DNA, or genomes, of all of the microbes that inhabit human skin—reveals that our skin is home to a much wider array of bacteria than previously thought. The accomplishment provides a new foundation for developing strategies to treat and prevent difficult skin diseases such as eczema, psoriasis, acne and antibiotic-resistant infections.
Photo of human skin.

The skin is one of the body’s first lines of defense against illness and injury. Its health depends upon the delicate balance between our own cells and the millions of bacteria and other one-celled microbes that live on its surface. To better understand this balance, NIH researchers drew on the power of modern DNA sequencing technology and computational analysis.

Scientists at NIH’s National Human Genome Research Institute (NHGRI), National Cancer Institute (NCI) and the NIH Clinical Center took skin samples from 20 sites on the bodies of 10 healthy volunteers. They extracted DNA from each sample and sequenced a type of gene that is specific to bacteria, the 16S ribosomal RNA gene.

The researchers reported in the journal Science on May 28, 2009, that they identified, classified and compared more than 112,000 bacterial gene sequences. Previous methods, which involved growing microbial samples from human skin in the laboratory, had uncovered a far less diverse collection.

The greatest influence on bacterial populations appears to be body location. For example, the bacteria that live under your arms likely are more similar to those under another person’s arm than they are to the bacteria on your own forearm. There was also considerable variation in the number of bacteria species at different sites, with the most diversity on the forearm (44 species on average) and the least diversity behind the ear (19 species on average).

In general, dry and moist skin had a broader variety of microbes than oily skin. Dry areas include the inside surface of the mid-forearm, the palm of the hand and the buttock. Moist areas include inside the nose, armpit and side of the groin. Oily sites include beside the nose, inside the ear and the upper chest and back.

To look for changes over time, the researchers sampled some volunteers twice, with the samples taken about 4 to 6 months apart. Most of the resampled volunteers were more like themselves over time than they were like other volunteers. However, the stability of the microbial community was dependent on the site surveyed. The greatest stability was found in samples from inside the ear and nose. The least stability was found in samples from behind the knee.

“Our results underscore that skin is home to vibrant communities of microbial life, which may significantly influence our health,” says Dr. Elizabeth Grice, a postdoctoral fellow at NHGRI and the study’s first author.

This study is among early research laying the groundwork for NIH’s Human Microbiome Project, which aims to characterize human microbial communities and their role in health and disease. Other efforts are sampling the microbiomes of the nose, digestive tract, mouth and vagina.
Related Links:

* Human Microbiome Project:

http://nihroadmap.nih.gov/hmp/

* Skin Diseases:

http://health.nih.gov/result.asp?terms=skin&disease;_id=599

Source: http://www.nih.gov/news/research_matters/june2009/06012009skin.htm

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